Podophyllum peltatum is the mandrake or May-apple, a plant that grows to the height of some two or three feet, with leaves spread out like an open hand. It is found mostly on the borders of woods. The parts used in medicine are the roots and fruit of the plant.
The central point of attack of the drug, however, is in the abdomen. Shortly after it is taken there follow diarrhoea, colicky pains, the well-
known morning stool pouring out like water from a hydrant, preceded by retching and vomiting and spasmodic contraction of the stomach,
making the child scream out. The stools are renewed immediately by eating.
It is indicated in the torpid or chronically congested liver. The liver is swollen and sensitive, and friction over the right hypochondrium relieves this sensation. The face and sclerotica become tinged yellow. There is bad taste in the mouth, evidently arising from the degeneration of food in
the intestinal tract. The tongue is coated yellow or white, and takes the imprint of the teeth. The bile may become inspissated in the gall
bladder, forming gall-stone; thus we find Podophyllum indicated in that tormenting disease, bilious colic. The stools are of the nature already mentioned; or they are constipated and clay-colored, showing the absense of bile. These symptoms of Podophyllum much resemble
those of Mercurius. They have won for the drug the name of vegetable mercury.
In constipation of bottle-fed babies Podophyllum will sometimes relieve. The stools are dry and crumbling.
Podophyllum also produces prolapsus recti with the diarrhoea. The rectum protrudes before stool , especially in the morning. Podophyllum also seems to have the power of producing and curing prolapsus of the uterus with attendant symptoms of bearing down in the hypogastric and sacral regions worse from motion, and neuralgia in the right ovary, extending down the anterior crural nerve, backache, retarded menses, thick transparent leucorrhcea and often coexisting with these, prolapsus recti.
Very few would think of Podophyllum as a remedy for tonsillitis and yet it has some very clear cut indications in this affection. The trouble
is apt to start in the right side and extend to the left, like Lycopodium. There is great dryness of the throat, aggravation from swallowing
liquids and in the morning and pain going into the ear.
Podophyllum is a valuable remedy during dentition. It does not seem to act on the brain, yet it causes reflex cerebral irritation, whether
this be from the abdominal symptoms alone or from the teeth. The symptoms which indicate it in addition to those already given are moaning and whining during sleep, not crying out with a sharp, sudden noise, as under Belladonna, but a sick cry; the child grates its teeth; the head is thrown back and rolled from side to side.
Next we find Podophyllum indicated in fevers, usually of a remittent type, particularly in bilious remittent fever. During the fever the patient is sleepy and sometimes delirious.